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The two forwards are facing a race against time to recover in time for the Man City clash after picking up injuries while on international duty. Gakpo is dealing with an ankle issue, while Isak withdrew from the Sweden squad with a thigh problem.
Andoni Iraola has confirmed this week that the medical staff will make a late decision on both attackers before the Sunday match.
In their absence, Liverpool would be really short on attacking options, especially up front, where the best remaining option would probably be Lewis Koumas.